No association between Parkinson disease alleles and the risk of melanoma.

ABSTRACT:

Background

Recent data showed that melanoma was more common among patients with Parkinson disease than individuals without Parkinson disease and vice versa. It has been hypothesized that these two diseases may share common genetic and environmental risk factors.

Methods

We evaluated the association between single-nucleotide polymorphisms (SNP) selected on the basis of recent genome-wide association studies (GWAS) on Parkinson disease risk and the risk of melanoma using 2,297 melanoma cases and 6,651 controls.

Results

The Parkinson disease SNP rs156429 in the chromosome 7p15 region was nominally associated with melanoma risk with P value of 0.04, which was not significant after the Bonferroni correction for multiple comparisons. No association was observed between the

SUBMITTER: Meng S 

PROVIDER: S-EPMC3253945 | biostudies-literature | 2012 Jan

REPOSITORIES: biostudies-literature