Genetic polymorphisms in pre-microRNA genes as prognostic markers of colorectal cancer.

ABSTRACT:

Background

Cumulative data have shown that microRNAs (miRNA) are involved in the etiology and prognosis of colorectal cancer (CRC). Genetic polymorphisms in pre-miRNA genes may influence the biogenesis and functions of their host miRNAs. However, whether these polymorphisms are associated with CRC prognosis remains unknown.

Methods

We analyzed the effects of seven single-nucleotide polymorphisms (SNP) in pre-miRNA genes on the prognosis of a Chinese population with 408 CRC patients with surgically-resected adenocarcinoma.

Results

Two SNPs were identified to be significantly associated with recurrence-free survival and overall survival of the patients. The most significant SNP was rs6505162 in pre-miR-423. Compared with the homozygous wild-type genotype, the variant-co

SUBMITTER: Xing J 

PROVIDER: S-EPMC3253954 | biostudies-literature | 2012 Jan

REPOSITORIES: biostudies-literature