Effect of radiotherapy after breast-conserving surgery on 10-year recurrence and 15-year breast cancer death: meta-analysis of individual patient data for 10,801 women in 17 randomised trials.

ABSTRACT:

Background

After breast-conserving surgery, radiotherapy reduces recurrence and breast cancer death, but it may do so more for some groups of women than for others. We describe the absolute magnitude of these reductions according to various prognostic and other patient characteristics, and relate the absolute reduction in 15-year risk of breast cancer death to the absolute reduction in 10-year recurrence risk.

Methods

We undertook a meta-analysis of individual patient data for 10,801 women in 17 randomised trials of radiotherapy versus no radiotherapy after breast-conserving surgery, 8337 of whom had pathologically confirmed node-negative (pN0) or node-positive (pN+) disease.

Findings

Overall, radiotherapy reduced the 10-year risk of any (ie, locoregional or distant)

SUBMITTER: Early Breast Cancer Trialists' Collaborative Group (EBCTCG) 

PROVIDER: S-EPMC3254252 | biostudies-literature | 2011 Nov

REPOSITORIES: biostudies-literature