Subject-specific changes in brain white matter on diffusion tensor imaging after sports-related concussion.

ABSTRACT:

Background and purpose

Current approaches to diffusion tensor imaging (DTI) analysis do not permit identification of individual-level changes in DTI indices. We investigated the ability of wild bootstrapping analysis to detect subject-specific changes in brain white matter (WM) before and after sports-related concussion.

Materials and methods

A prospective cohort study was performed in nine high school athletes engaged in hockey or football and six controls. Subjects underwent DTI pre- and postseason within a 3-month interval. One athlete was diagnosed with concussion (scanned within 72 h), and eight suffered between 26 and 399 subconcussive head blows. Fractional anisotropy (FA) and mean diffusivity (MD) were measured in each WM voxel. Bootstrap samples were generated, and

SUBMITTER: Bazarian JJ 

PROVIDER: S-EPMC3254806 | biostudies-literature | 2012 Feb

REPOSITORIES: biostudies-literature