Higher risk of venous thrombosis associated with drospirenone-containing oral contraceptives: a population-based cohort study.

ABSTRACT:

Background

Combined oral contraceptives are a common method of contraception, but they carry a risk of venous and arterial thrombosis. We assessed whether use of drospirenone was associated with an increase in thrombotic risk relative to third-generation combined oral contraceptives.

Methods

Using computerized records of the largest health care provider in Israel, we identified all women aged 12 to 50 years for whom combined oral contraceptives had been dispensed between Jan. 1, 2002, and Dec. 31, 2008. We followed the cohort until 2009. We used Poisson regression models to estimate the crude and adjusted rate ratios for risk factors for venous thrombotic events (specifically deep vein thrombosis and pulmonary embolism) and arterial thromboic events (specifically transient i

SUBMITTER: Gronich N 

PROVIDER: S-EPMC3255137 | biostudies-literature | 2011 Dec

REPOSITORIES: biostudies-literature