Associations between first and second primary cancers: a population-based study.

ABSTRACT:

Background

Patients surviving certain types of cancer are at increased risk of a second primary cancer. We tested the hypothesis that excess risk of a second primary cancer is due mainly to excess risk of it being the same type of cancer as the first, rather than to excess risk of it being a different type.

Methods

We conducted a nationwide study using data from three dabatases for the entire Danish population (n = 7,493,705) from 1980 through 2007. For each type of cancer, we performed a nested study matching each patient with incident cancer diagnosed in that period with up to five controls who did not have the examined cancer at the time of diagnosis. We used Cox regression models to calculate individual risk estimates and meta-analysis techniques to calculate aggregated

SUBMITTER: Nielsen SF 

PROVIDER: S-EPMC3255183 | biostudies-literature | 2012 Jan

REPOSITORIES: biostudies-literature