Important but differential roles for actin in trafficking of Epstein-Barr virus in B cells and epithelial cells.

ABSTRACT: Epstein-Barr virus (EBV) uses different virus and cell proteins to enter its two major targets, B lymphocytes and epithelial cells. The routes that the virus takes into the two cell types are also different. To determine if these differences extend to movement from the cell surface to the nucleus, we examined the fate of incoming virus. Essentially all virus that entered a B cell remained stable for at least 8 h. In contrast, up to 80% of virus entering an epithelial cell was degraded in a compartment sensitive to inhibitors of components involved in autophagy. Inhibitors of actin remodeling blocked entry into a B cell but had no effect or enhanced entry into an epithelial cell. Inhibitors of the microtubule network reduced intracellular transport in both cell types, but movement to the nu

SUBMITTER: Valencia SM 

PROVIDER: S-EPMC3255874 | biostudies-literature | 2012 Jan

REPOSITORIES: biostudies-literature