Viral expression directs the fate of B cells in bovine leukemia virus-infected sheep.
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ABSTRACT:
SUBMITTER: Florins A
PROVIDER: S-EPMC3255919 | biostudies-literature | 2012 Jan
REPOSITORIES: biostudies-literature
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Viral expression directs the fate of B cells in bovine leukemia virus-infected sheep.
Florins Arnaud A de Brogniez Alix A Elemans Marjet M Bouzar Amel-Baya AB François Carole C Reichert Michal M Asquith Becca B Willems Luc L
Journal of virology 20111026 1
The host immune response is believed to tightly control viral replication of deltaretroviruses such as human T-lymphotropic virus type 1 (HTLV-1) and bovine leukemia virus (BLV). However, this assumption has not been definitely proven in vivo. In order to further evaluate the importance of the immune response in the BLV model, we studied the fate of cells in which viral expression was transiently induced. Using a dual fluorochrome labeling approach, we showed that ex vivo induction of viral expr ...[more]
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