Global transcriptome changes underlying colony growth in the opportunistic human pathogen Aspergillus fumigatus.

ABSTRACT: Aspergillus fumigatus is the most common and deadly pulmonary fungal infection worldwide. In the lung, the fungus usually forms a dense colony of filaments embedded in a polymeric extracellular matrix. To identify candidate genes involved in this biofilm (BF) growth, we used RNA-Seq to compare the transcriptomes of BF and liquid plankton (PL) growth. Sequencing and mapping of tens of millions sequence reads against the A. fumigatus transcriptome identified 3,728 differentially regulated genes in the two conditions. Although many of these genes, including the ones coding for transcription factors, stress response, the ribosome, and the translation machinery, likely reflect the different growth demands in the two conditions, our experiment also identified hundreds of candidate genes for the

SUBMITTER: Gibbons JG 

PROVIDER: S-EPMC3255943 | biostudies-literature | 2012 Jan

REPOSITORIES: biostudies-literature