Measures of association for identifying microRNA-mRNA pairs of biological interest.

ABSTRACT: MicroRNAs are a class of small non-protein coding RNAs that play an important role in the regulation of gene expression. Most studies on the identification of microRNA-mRNA pairs utilize the correlation coefficient as a measure of association. The use of correlation coefficient is appropriate if the expression data are available for several conditions and, for a given condition, both microRNA and mRNA expression profiles are obtained from the same set of individuals. However, there are many instances where one of the requirements is not satisfied. Therefore, there is a need for new measures of association to identify the microRNA-mRNA pairs of interest and we present two such measures. The first measure requires expression data for multiple conditions but, for a given condition, the microR

SUBMITTER: Jayaswal V 

PROVIDER: S-EPMC3256172 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature