Multiple pathway-based genetic variations associated with tobacco related multiple primary neoplasms.

ABSTRACT:

Background

In order to elucidate a combination of genetic alterations that drive tobacco carcinogenesis we have explored a unique model system and analytical method for an unbiased qualitative and quantitative assessment of gene-gene and gene-environment interactions. The objective of this case control study was to assess genetic predisposition in a biologically enriched clinical model system of tobacco related cancers (TRC), occurring as Multiple Primary Neoplasms (MPN).

Methods

Genotyping of 21 candidate Single Nucleotide Polymorphisms (SNP) from major metabolic pathways was performed in a cohort of 151 MPN cases and 210 cancer-free controls. Statistical analysis using logistic regression and Multifactor Dimensionality Reduction (MDR) analysis was performed for studying hi

SUBMITTER: Kotnis A 

PROVIDER: S-EPMC3256192 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature