Comprehensive transcriptome analysis of the periodontopathogenic bacterium Porphyromonas gingivalis W83.

ABSTRACT: High-density tiling microarray and RNA sequencing technologies were used to analyze the transcriptome of the periodontopathogenic bacterium Porphyromonas gingivalis. The compiled P. gingivalis transcriptome profiles were based on total RNA samples isolated from three different laboratory culturing conditions, and the strand-specific transcription profiles generated covered the entire genome, including both protein coding and noncoding regions. The transcription profiles revealed various operon structures, 5'- and 3'-end untranslated regions (UTRs), differential expression patterns, and many novel, not-yet-annotated transcripts within intergenic and antisense regions. Further transcriptome analysis identified the majority of the genes as being expressed within operons and most 5' and 3' end

SUBMITTER: Hovik H 

PROVIDER: S-EPMC3256594 | biostudies-literature | 2012 Jan

REPOSITORIES: biostudies-literature