Determinants of microvascular network topologies in implanted neovasculatures.

ABSTRACT:

Objective

During neovascularization, the end result is a new functional microcirculation composed of a network of mature microvessels with specific topologies. Although much is known concerning the mechanisms underlying the initiation of angiogenesis, it remains unclear how the final architecture of microcirculatory beds is regulated. To begin to address this, we determined the impact of angiogenic neovessel prepatterning on the final microvascular network topology using a model of implant neovascularization.

Methods and results

We used 3D direct-write bioprinting or physical constraints in a manner permitting postangiogenesis vascular remodeling and adaptation to pattern angiogenic microvascular precursors (neovessels formed from isolated microvessel segments) in 3D collage

SUBMITTER: Chang CC 

PROVIDER: S-EPMC3256738 | biostudies-literature | 2012 Jan

REPOSITORIES: biostudies-literature