Determinants of per-coital-act HIV-1 infectivity among African HIV-1-serodiscordant couples.

ABSTRACT:

Background

Knowledge of factors that affect per-act infectivity of human immunodeficiency virus type 1 (HIV-1) is important for designing HIV-1 prevention interventions and for the mathematical modeling of the spread of HIV-1.

Methods

We analyzed data from a prospective study of African HIV-1-serodiscordant couples. We assessed transmissions for linkage within the study partnership, based on HIV-1 sequencing. The primary exposure measure was the HIV-1-seropositive partners' reports of number of sex acts and condom use with their study partner.

Results

Of 3297 couples experiencing 86 linked HIV-1 transmissions, the unadjusted per-act risks of unprotected male-to-female (MTF) and female-to-male (FTM) transmission were 0.0019 (95% confidence interval [CI], .0010-.0037) a

SUBMITTER: Hughes JP 

PROVIDER: S-EPMC3256946 | biostudies-literature | 2012 Feb

REPOSITORIES: biostudies-literature