Extensive intron gain in the ancestor of placental mammals.

ABSTRACT:

Background

Genome-wide studies of intron dynamics in mammalian orthologous genes have found convincing evidence for loss of introns but very little for intron turnover. Similarly, large-scale analysis of intron dynamics in a few vertebrate genomes has identified only intron losses and no gains, indicating that intron gain is an extremely rare event in vertebrate evolution. These studies suggest that the intron-rich genomes of vertebrates do not allow intron gain. The aim of this study was to search for evidence of de novo intron gain in domesticated genes from an analysis of their exon/intron structures.

Results

A phylogenomic approach has been used to analyse all domesticated genes in mammals and chordates that originated from the coding parts of transposable elements. Gain

SUBMITTER: Kordis D 

PROVIDER: S-EPMC3257199 | biostudies-literature | 2011 Nov

REPOSITORIES: biostudies-literature