Ontology highlight
ABSTRACT:
SUBMITTER: Alexandrov IM
PROVIDER: S-EPMC3257279 | biostudies-literature | 2012 Jan
REPOSITORIES: biostudies-literature
PLoS genetics 20120112 1
The cytoplasmic polyadenylation element binding protein CPEB1 (CPEB) regulates germ cell development, synaptic plasticity, and cellular senescence. A microarray analysis of mRNAs regulated by CPEB unexpectedly showed that several encoded proteins are involved in insulin signaling. An investigation of Cpeb1 knockout mice revealed that the expression of two particular negative regulators of insulin action, PTEN and Stat3, were aberrantly increased. Insulin signaling to Akt was attenuated in livers ...[more]