Genetic polymorphisms in adaptive immunity genes and childhood acute lymphoblastic leukemia.

ABSTRACT:

Background

Childhood acute lymphoblastic leukemia (ALL) has been hypothesized to have an infection- and immune-related etiology. The lack of immune priming in early childhood may result in abnormal immune responses to infections later in life and increase ALL risk.

Methods

The current analyses examined the association between childhood ALL and 208 single-nucleotide polymorphisms (SNP) of 29 adaptive immune function genes among 377 ALL cases and 448 healthy controls. Single SNPs were analyzed with a log-additive approach using logistic regression models adjusted for sex, age, Hispanic ethnicity, and race. Sliding window haplotype analyses were done with haplotypes consisting of 2 to 6 SNPs.

Results

Of the 208 SNPs, only rs583911 of IL12A, which encodes a critical modul

SUBMITTER: Chang JS 

PROVIDER: S-EPMC3257312 | biostudies-literature | 2010 Sep

REPOSITORIES: biostudies-literature