Modeling the Calvin-Benson cycle.

ABSTRACT:

Background

Modeling the Calvin-Benson cycle has a history in the field of theoretical biology. Anyone who intends to model this system will look at existing models to adapt, refine and improve them. With the goal to study the regulation of carbon metabolism, we investigated a broad range of relevant models for their suitability to provide the basis for further modeling efforts. Beyond a critical analysis of existing models, we furthermore investigated the question how adjacent metabolic pathways, for instance photorespiration, can be integrated in such models.

Results

Our analysis reveals serious problems with a range of models that are publicly available and widely used. The problems include the irreproducibility of the published results or significant differences between t

SUBMITTER: Jablonsky J 

PROVIDER: S-EPMC3257313 | biostudies-literature | 2011 Nov

REPOSITORIES: biostudies-literature