PET/MRI of inflammation in myocardial infarction.

ABSTRACT:

Objectives

The aim of this study was to explore post-myocardial infarction (MI) myocardial inflammation.

Background

Innate immune cells are centrally involved in infarct healing and are emerging therapeutic targets in cardiovascular disease; however, clinical tools to assess their presence in tissue are scarce. Furthermore, it is currently not known if the nonischemic remote zone recruits monocytes.

Methods

Acute inflammation was followed in mice with coronary ligation by 18-fluorodeoxyglucose ((18)FDG) positron emission tomography/magnetic resonance imaging, fluorescence-activated cell sorting, polymerase chain reaction, and histology.

Results

Gd-DTPA-enhanced infarcts showed high (18)FDG uptake on day 5 after MI. Cell depletion and isolation data confirmed th

SUBMITTER: Lee WW 

PROVIDER: S-EPMC3257823 | biostudies-literature | 2012 Jan

REPOSITORIES: biostudies-literature