Treatment of Resistant Depression in Adolescents (TORDIA): week 24 outcomes.

ABSTRACT:

Objective

The purpose of this study was to report on the outcome of participants in the Treatment of Resistant Depression in Adolescents (TORDIA) trial after 24 weeks of treatment, including remission and relapse rates and predictors of treatment outcome.

Method

Adolescents (ages 12-18 years) with selective serotonin reuptake inhibitor (SSRI)-resistant depression were randomly assigned to either a medication switch alone (alternate SSRI or venlafaxine) or a medication switch plus cognitive-behavioral therapy (CBT). At week 12, responders could continue in their assigned treatment arm and nonresponders received open treatment (medication and/or CBT) for 12 more weeks (24 weeks total). The primary outcomes were remission and relapse, defined by the Adolescent Longitudinal Inte

SUBMITTER: Emslie GJ 

PROVIDER: S-EPMC3257891 | biostudies-literature | 2010 Jul

REPOSITORIES: biostudies-literature