Insight into bacterial virulence mechanisms against host immune response via the Yersinia pestis-human protein-protein interaction network.

ABSTRACT: A Yersinia pestis-human protein interaction network is reported here to improve our understanding of its pathogenesis. Up to 204 interactions between 66 Y. pestis bait proteins and 109 human proteins were identified by yeast two-hybrid assay and then combined with 23 previously published interactions to construct a protein-protein interaction network. Topological analysis of the interaction network revealed that human proteins targeted by Y. pestis were significantly enriched in the proteins that are central in the human protein-protein interaction network. Analysis of this network showed that signaling pathways important for host immune responses were preferentially targeted by Y. pestis, including the pathways involved in focal adhesion, regulation of cytoskeleton, leukocyte transendoepi

SUBMITTER: Yang H 

PROVIDER: S-EPMC3257920 | biostudies-literature | 2011 Nov

REPOSITORIES: biostudies-literature