Genetic variants and environmental factors associated with hormonal markers of ovarian reserve in Caucasian and African American women.

ABSTRACT:

Background

The ovarian reserve (number and quality of oocytes) is correlated with reproductive potential as well as somatic health, and is likely to have multiple genetic and environmental determinants. Several reproductive hormones are closely linked with the oocyte pool and thus can serve as surrogate markers of ovarian reserve. However, we know little about the underlying genes or genetic variants.

Methods

We analyzed genetic variants across the genome associated with two hormonal markers of ovarian reserve, FSH and anti-Mullerian hormone, in a reproductively normal population of Caucasian (n = 232) and African American (n = 200) women, aged 25-45 years. We also examined the effects of environmental or lifestyle factors on ovarian reserve phenotypes.

Results

We ide

SUBMITTER: Schuh-Huerta SM 

PROVIDER: S-EPMC3258032 | biostudies-literature | 2012 Feb

REPOSITORIES: biostudies-literature