MetaQC: objective quality control and inclusion/exclusion criteria for genomic meta-analysis.

ABSTRACT: Genomic meta-analysis to combine relevant and homogeneous studies has been widely applied, but the quality control (QC) and objective inclusion/exclusion criteria have been largely overlooked. Currently, the inclusion/exclusion criteria mostly depend on ad-hoc expert opinion or naïve threshold by sample size or platform. There are pressing needs to develop a systematic QC methodology as the decision of study inclusion greatly impacts the final meta-analysis outcome. In this article, we propose six quantitative quality control measures, covering internal homogeneity of coexpression structure among studies, external consistency of coexpression pattern with pathway database, and accuracy and consistency of differentially expressed gene detection or enriched pathway identification. Each qualit

SUBMITTER: Kang DD 

PROVIDER: S-EPMC3258120 | biostudies-literature | 2012 Jan

REPOSITORIES: biostudies-literature