An integrative genomic approach identifies p73 and p63 as activators of miR-200 microRNA family transcription.

ABSTRACT: Although microRNAs (miRNAs) are important regulators of gene expression, the transcriptional regulation of miRNAs themselves is not well understood. We employed an integrative computational pipeline to dissect the transcription factors (TFs) responsible for altered miRNA expression in ovarian carcinoma. Using experimental data and computational predictions to define miRNA promoters across the human genome, we identified TFs with binding sites significantly overrepresented among miRNA genes overexpressed in ovarian carcinoma. This pipeline nominated TFs of the p53/p63/p73 family as candidate drivers of miRNA overexpression. Analysis of data from an independent set of 253 ovarian carcinomas in The Cancer Genome Atlas showed that p73 and p63 expression is significantly correlated with express

SUBMITTER: Knouf EC 

PROVIDER: S-EPMC3258134 | biostudies-literature | 2012 Jan

REPOSITORIES: biostudies-literature