Modeling the relative relationship of transcription factor binding and histone modifications to gene expression levels in mouse embryonic stem cells.

ABSTRACT: Transcription factor (TF) binding and histone modification (HM) are important for the precise control of gene expression. Hence, we constructed statistical models to relate these to gene expression levels in mouse embryonic stem cells. While both TF binding and HMs are highly 'predictive' of gene expression levels (in a statistical, but perhaps not strictly mechanistic, sense), we find they show distinct differences in the spatial patterning of their predictive strength: TF binding achieved the highest predictive power in a small DNA region centered at the transcription start sites of genes, while the HMs exhibited high predictive powers across a wide region around genes. Intriguingly, our results suggest that TF binding and HMs are redundant in strict statistical sense for predicting gene

SUBMITTER: Cheng C 

PROVIDER: S-EPMC3258143 | biostudies-literature | 2012 Jan

REPOSITORIES: biostudies-literature