Plasmodium vivax lineages: geographical distribution, tandem repeat polymorphism, and phylogenetic relationship.

ABSTRACT:

Background

Multi-drug resistance and severe/complicated cases are the emerging phenotypes of vivax malaria, which may deteriorate current anti-malarial control measures. The emergence of these phenotypes could be associated with either of the two Plasmodium vivax lineages. The two lineages had been categorized as Old World and New World, based on geographical sub-division and genetic and phenotypical markers. This study revisited the lineage hypothesis of P. vivax by typing the distribution of lineages among global isolates and evaluated their genetic relatedness using a panel of new mini-satellite markers.

Methods

18S SSU rRNA S-type gene was amplified from 420 Plasmodium vivax field isolates collected from different geographical regions of India, Thailand and Colombia as w

SUBMITTER: Prajapati SK 

PROVIDER: S-EPMC3258263 | biostudies-literature | 2011 Dec

REPOSITORIES: biostudies-literature