Identification of proprotein convertase substrates using genome-wide expression correlation analysis.

ABSTRACT:

Background

Subtilisin/kexin-like proprotein convertase (PCSK) enzymes have important regulatory function in a wide variety of biological processes. PCSKs proteolytically process at a target sequence that contains basic amino acids arginine and lysine, which results in functional maturation of the target protein. In vitro assays have showed significant biochemical redundancy between the seven family members, but the phenotypes of PCSK deficient mice and patients carrying an inactive PCSK allele argue for a specific biological function. Modeling the structures of individual PCSK enzymes has offered little insights into the specificity determinants. However, previous studies have shown that there can be a coordinated expression between a PCSK and its target molecule. Here, we have sur

SUBMITTER: Turpeinen H 

PROVIDER: S-EPMC3258279 | biostudies-literature | 2011 Dec

REPOSITORIES: biostudies-literature