The odds of duplicate gene persistence after polyploidization.

ABSTRACT:

Background

Gene duplication is an important biological phenomenon associated with genomic redundancy, degeneration, specialization, innovation, and speciation. After duplication, both copies continue functioning when natural selection favors duplicated protein function or expression, or when mutations make them functionally distinct before one copy is silenced.

Results

Here we quantify the degree to which genetic parameters related to gene expression, molecular evolution, and gene structure in a diploid frog - Silurana tropicalis - influence the odds of functional persistence of orthologous duplicate genes in a closely related tetraploid species - Xenopus laevis. Using public databases and 454 pyrosequencing, we obtained genetic and expression data from S. tropicalis ortholo

SUBMITTER: Chain FJ 

PROVIDER: S-EPMC3258412 | biostudies-literature | 2011 Dec

REPOSITORIES: biostudies-literature