Acute effects of orexigenic antipsychotic drugs on lipid and carbohydrate metabolism in rat.

ABSTRACT:

Objective

This study aims to investigate whether orexigenic antipsychotic drugs may induce dyslipidemia and glucose disturbances in female rats through direct perturbation of metabolically active peripheral tissues, independent of prior weight gain.

Methods

In the current study, we examined whether a single intraperitoneal injection of clozapine or olanzapine induced metabolic disturbances in adult female outbred Sprague-Dawley rats. Serum glucose and lipid parameters were measured during time-course experiments up to 48 h. Real-time quantitative PCR was used to measure specific transcriptional alterations in lipid and carbohydrate metabolism in adipose tissue depots or in the liver.

Results

Our results demonstrated that acute administration of clozapine or olanzapine

SUBMITTER: Jassim G 

PROVIDER: S-EPMC3259403 | biostudies-literature | 2012 Feb

REPOSITORIES: biostudies-literature