Immunohistological localization of BMP-2, BMP-7, and their receptors in knee joints with focal cartilage lesions.

ABSTRACT:

Introduction

Although it is well known that BMP-2 and BMP-7 play significant roles in cartilage metabolism, data about intra-articular expression and localization of these proteins and their receptors in humans are rare.

Methods

Biopsies of synovia and debrided cartilage were taken in patients undergoing autologous chondrocyte implantation. Expression of BMP-2, BMP-7, and their receptors BMPR-1A, BMPR-1B and BMPR-2 were semiquantitatively evaluated by immunohistological staining.

Results

BMP-7 was equally highly expressed in all cartilage and synovial biopsies. Increased levels of BMPR-1A, but not of BMPR-1B, and BMPR-2, were found in all synovial and 47% of all cartilage samples (P = 0.002). BMP-2 was positively scored in 47% of all cartilage and 40% of all synovial

SUBMITTER: Schmal H 

PROVIDER: S-EPMC3259605 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature