Efficacy and safety of a short course of very-high-dose cholecalciferol in hemodialysis.

ABSTRACT:

Background

Vitamin D deficiency is highly prevalent among hemodialysis patients, but little data exist in support of an optimal repletion regimen.

Objective

The objective was to ascertain the efficacy of weekly very-high-dose cholecalciferol (vitamin D(3)) in correcting vitamin D insufficiency and deficiency in patients with stage 5D chronic kidney disease.

Design

We conducted a prospective, double-blind, randomized controlled pilot study that compared placebo with very high doses of oral cholecalciferol for 3 wk (200,000 IU/wk) in hemodialysis patients. We examined the rate of correction of vitamin D insufficiency or deficiency and the effect of treatment on markers of mineral metabolism and routine laboratory variables.

Results

Twenty-seven subjects received

SUBMITTER: Wasse H 

PROVIDER: S-EPMC3260077 | biostudies-literature | 2012 Feb

REPOSITORIES: biostudies-literature