Candidate gene analysis of spontaneous preterm delivery: new insights from re-analysis of a case-control study using case-parent triads and control-mother dyads.

ABSTRACT:

Background

Spontaneous preterm delivery (PTD) has a multifactorial etiology with evidence of a genetic contribution to its pathogenesis. A number of candidate gene case-control studies have been performed on spontaneous PTD, but the results have been inconsistent, and do not fully assess the role of how two genotypes can impact outcome. To elucidate this latter point we re-analyzed data from a previously published case-control candidate gene study, using a case-parent triad design and a hybrid design combining case-parent triads and control-mother dyads. These methods offer a robust approach to genetic association studies for PTD compared to traditional case-control designs.

Methods

The study participants were obtained from the Norwegian Mother and Child Cohort Study (MoBa).

SUBMITTER: Myking S 

PROVIDER: S-EPMC3260094 | biostudies-literature | 2011 Dec

REPOSITORIES: biostudies-literature