Association between Helicobacter pylori cagA-related genes and clinical outcomes in Colombia and Japan.

ABSTRACT:

Background

Specific genotypes of several virulence factors of Helicobacter pylori (eg, cagA-positive, vacA s1, oipA "on" and babA-positive) have been reported to be predictors of severe clinical outcomes. Importantly, the presence of these genotypes correlates with each other. We hypothesized that novel virulence genes correlate with the presence of cagA. Therefore, we aimed to find novel candidate virulence genes that correlate with cagA and examined the association of these genes with clinical outcomes in Colombian and Japanese populations.

Methods

cagA-associated genes were selected based on previous H. pylori genome microarray data. A total of 343 strains (174 from Colombia and 169 from Japan) were examined for the status of cagA, vacA, and candidate genes by polymerase

SUBMITTER: Watada M 

PROVIDER: S-EPMC3260095 | biostudies-literature | 2011 Dec

REPOSITORIES: biostudies-literature