InterSCOPE study: Associations between esophageal squamous cell carcinoma and human papillomavirus serological markers.

ABSTRACT:

Background

The role of human papillomavirus (HPV) in the causation of esophageal squamous cell carcinoma is unclear. We examined the associations between esophageal squamous cell carcinoma and 28 centrally measured HPV serological markers in serum from six existing case-control studies conducted in regions with differing background risks of esophageal cancer.

Methods

We used centralized multiplex serology to test serum samples from 1561 case subjects and 2502 control subjects from six case-control studies for antibodies to the major HPV capsid protein (L1) and/or the early proteins E6 and/or E7 of eight high-risk, two low-risk, and four cutaneous HPV types. Study-specific odds ratios (ORs) and corresponding 95% confidence intervals (CIs) were estimated using conditional logi

SUBMITTER: Sitas F 

PROVIDER: S-EPMC3260131 | biostudies-literature | 2012 Jan

REPOSITORIES: biostudies-literature