Identification of a potential ovarian cancer stem cell gene expression profile from advanced stage papillary serous ovarian cancer.

ABSTRACT: Identification of gene expression profiles of cancer stem cells may have significant implications in the understanding of tumor biology and for the design of novel treatments targeted toward these cells. Here we report a potential ovarian cancer stem cell gene expression profile from isolated side population of fresh ascites obtained from women with high-grade advanced stage papillary serous ovarian adenocarcinoma. Affymetrix U133 Plus 2.0 microarrays were used to interrogate the differentially expressed genes between side population (SP) and main population (MP), and the results were analyzed by paired T-test using BRB-ArrayTools. We identified 138 up-regulated and 302 down-regulated genes that were differentially expressed between all 10 SP/MP pairs. Microarray data was validated using q

SUBMITTER: Vathipadiekal V 

PROVIDER: S-EPMC3260150 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature