Straightforward inference of ancestry and admixture proportions through ancestry-informative insertion deletion multiplexing.

ABSTRACT: Ancestry-informative markers (AIMs) show high allele frequency divergence between different ancestral or geographically distant populations. These genetic markers are especially useful in inferring the likely ancestral origin of an individual or estimating the apportionment of ancestry components in admixed individuals or populations. The study of AIMs is of great interest in clinical genetics research, particularly to detect and correct for population substructure effects in case-control association studies, but also in population and forensic genetics studies. This work presents a set of 46 ancestry-informative insertion deletion polymorphisms selected to efficiently measure population admixture proportions of four different origins (African, European, East Asian and Native American). Al

SUBMITTER: Pereira R 

PROVIDER: S-EPMC3260179 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature