Three-dimensional stochastic off-lattice model of binding chemistry in crowded environments.

ABSTRACT: Molecular crowding is one of the characteristic features of the intracellular environment, defined by a dense mixture of varying kinds of proteins and other molecules. Interaction with these molecules significantly alters the rates and equilibria of chemical reactions in the crowded environment. Numerous fundamental activities of a living cell are strongly influenced by the crowding effect, such as protein folding, protein assembly and disassembly, enzyme activity, and signal transduction. Quantitatively predicting how crowding will affect any particular process is, however, a very challenging problem because many physical and chemical parameters act synergistically in ways that defy easy analysis. To build a more realistic model for this problem, we extend a prior stochastic off-lattice m

SUBMITTER: Lee B 

PROVIDER: S-EPMC3260218 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature