Cue-induced reinstatement of cocaine seeking in the rat "conflict model": effect of prolonged home-cage confinement.

ABSTRACT:

Rationale and objectives

Drug addiction is not just the repeated administration of drugs, but compulsive drug use maintained despite the accumulation of adverse consequences for the user. In an attempt to introduce adverse consequences of drug seeking to laboratory animals, we have developed the "conflict model," in which the access of rats to a reinforcing lever allowing self-administration requires passing of an electrified grid floor. In this model, the current intensity leading to complete abstinence from drug seeking can be measured individually. The present study was designed to evaluated whether reinstatement of drug or natural reward seeking, despite the presence of the electrical barrier, can be achieved by presentation of discrete cues that were associated with the reward

SUBMITTER: Barnea-Ygael N 

PROVIDER: S-EPMC3260342 | biostudies-literature | 2012 Feb

REPOSITORIES: biostudies-literature