Gβ5-RGS complexes are gatekeepers of hyperactivity involved in control of multiple neurotransmitter systems.

ABSTRACT:

Rationale and objectives

Our knowledge about genes involved in the control of basal motor activity that may contribute to the pathology of the hyperactivity disorders, e.g., attention deficit hyperactivity disorder (ADHD), is limited. Disruption of monoamine neurotransmitter signaling through G protein-coupled receptors (GPCR) is considered to be a major contributing factor to the etiology of the ADHD. Genetic association evidence and functional data suggest that regulators of G protein signaling proteins of the R7 family (R7 RGS) that form obligatory complexes with type 5 G protein beta subunit (Gβ5) and negatively regulate signaling downstream from monoamine GPCRs may play a role in controlling hyperactivity.

Methods

To test this hypothesis, we conducted behavioral, pharma

SUBMITTER: Xie K 

PROVIDER: S-EPMC3260372 | biostudies-literature | 2012 Feb

REPOSITORIES: biostudies-literature