Post-genomic update on a classical candidate gene for coronary artery disease: ESR1.

ABSTRACT:

Background

After age, sex is the most important risk factor for coronary artery disease (CAD). The mechanism through which women are protected from CAD is still largely unknown, but the observed sex difference suggests the involvement of the reproductive steroid hormone signaling system. Genetic association studies of the gene-encoding Estrogen Receptor α (ESR1) have shown conflicting results, although only a limited range of variation in the gene has been investigated.

Methods and results

We exploited information made available by advanced new methods and resources in complex disease genetics to revisit the question of ESR1's role in risk of CAD. We performed a meta-analysis of 14 genome-wide association studies (CARDIoGRAM discovery analysis, N=≈87,000) to search for popul

SUBMITTER: Lucas G 

PROVIDER: S-EPMC3260440 | biostudies-literature | 2011 Dec

REPOSITORIES: biostudies-literature