Use of risk reclassification with multiple biomarkers improves mortality prediction in acute lung injury.

ABSTRACT:

Objective

Multiple single biomarkers have been associated with poor outcomes in acute lung injury; however, no single biomarker has sufficient discriminating power to clearly indicate prognosis. Using both derivation and replication cohorts, we tested novel risk reclassification methods to determine whether measurement of multiple plasma biomarkers at the time of acute lung injury diagnosis would improve mortality prediction in acute lung injury.

Design

Analysis of plasma biomarker levels and prospectively collected clinical data from patients enrolled in two randomized controlled trials of ventilator therapy for acute lung injury.

Setting

Intensive care units of university hospitals participating in the National Institutes of Health Acute Respiratory Distress Syndrom

SUBMITTER: Calfee CS 

PROVIDER: S-EPMC3260884 | biostudies-literature | 2011 Apr

REPOSITORIES: biostudies-literature