People of the British Isles: preliminary analysis of genotypes and surnames in a UK-control population.

ABSTRACT: There is a great deal of interest in a fine-scale population structure in the UK, both as a signature of historical immigration events and because of the effect population structure may have on disease association studies. Although population structure appears to have a minor impact on the current generation of genome-wide association studies, it is likely to have a significant part in the next generation of studies designed to search for rare variants. A powerful way of detecting such structure is to control and document carefully the provenance of the samples involved. In this study, we describe the collection of a cohort of rural UK samples (The People of the British Isles), aimed at providing a well-characterised UK-control population that can be used as a resource by the research comm

SUBMITTER: Winney B 

PROVIDER: S-EPMC3260910 | biostudies-literature | 2012 Feb

REPOSITORIES: biostudies-literature