Modularity in protein complex and drug interactions reveals new polypharmacological properties.

ABSTRACT: Recent studies have highlighted the importance of interconnectivity in a large range of molecular and human disease-related systems. Network medicine has emerged as a new paradigm to deal with complex diseases. Connections between protein complexes and key diseases have been suggested for decades. However, it was not until recently that protein complexes were identified and classified in sufficient amounts to carry out a large-scale analysis of the human protein complex system. We here present the first systematic and comprehensive set of relationships between protein complexes and associated drugs and analyzed their topological features. The network structure is characterized by a high modularity, both in the bipartite graph and in its projections, indicating that its topology is highly d

SUBMITTER: Nacher JC 

PROVIDER: S-EPMC3261189 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature