Association of ADAMTS13 polymorphism with cerebral malaria.

ABSTRACT:

Background

Cerebral malaria is one of the most severe manifestations of Plasmodium falciparum malaria. The sequestration of parasitized red blood cells (PRBCs) to brain microvascular endothelium has been shown to contribute to the pathophysiology of cerebral malaria. Recent studies reported increased levels of von Willebrand factor (VWF) and reduced activity of VWF-cleaving protease, ADAMTS13 (a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13), in patients with cerebral malaria.

Methods

Association of six single nucleotide polymorphisms (SNPs) of the ADAMTS13 gene with cerebral malaria was examined in 708 Thai patients with P. falciparum malaria.

Results

Among six SNPs, the derived allele of a SNP located in intron 28, rs4962153-A, was

SUBMITTER: Kraisin S 

PROVIDER: S-EPMC3261218 | biostudies-literature | 2011 Dec

REPOSITORIES: biostudies-literature