Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.

ABSTRACT:

Purpose

Metastasis is responsible for the death of most cancer patients, yet few therapeutic agents are available which specifically target the molecular events that lead to metastasis. We recently showed that inactivating mutations in the tumor suppressor gene BAP1 are closely associated with loss of melanocytic differentiation in uveal melanoma (UM) and metastasis. The purpose of this study was to identify therapeutic agents that reverse the phenotypic effects of BAP1 loss in UM.

Experimental design

In silico screens were done to identify therapeutic compounds predicted to differentiate UM cells using Gene Set Enrichment Analysis and Connectivity Map databases. Valproic acid (VPA), trichostatin A, LBH-589, and suberoylanilide hydroxamic acid were evaluated for their effect

SUBMITTER: Landreville S 

PROVIDER: S-EPMC3261307 | biostudies-literature | 2012 Jan

REPOSITORIES: biostudies-literature