A novel role for matrix metalloproteinase-8 in sepsis.

ABSTRACT:

Objectives

Matrix metalloproteinase-8 messenger RNA expression was previously found to be increased in whole blood of children with septic shock. The impact of this finding on the severity and inflammatory response to sepsis is unknown. Here, we investigate the relationship between matrix metalloproteinase-8 and disease severity in children with septic shock. We further corroborate the role of matrix metalloproteinase-8 in sepsis in a murine model.

Design

Retrospective observational clinical study and randomized controlled laboratory experiments.

Setting

Pediatric intensive care units and an animal research facility at an academic children's hospital.

Patients and subjects

Patients age ≤10 yrs admitted to the intensive care unit with a diagnosis of septic shock

SUBMITTER: Solan PD 

PROVIDER: S-EPMC3261337 | biostudies-literature | 2012 Feb

REPOSITORIES: biostudies-literature