A polymorphism within ErbB4 is associated with risk for hepatocellular carcinoma in Chinese population.

ABSTRACT:

Aim

To investigate the association between hepatocellular carcinoma (HCC) susceptibility and a 12-bp insertion/deletion polymorphism (rs6147150) in the 3'UTR of ErbB4.

Methods

Using a case-control design, the rs6147150 genotypes in 270 patients with HCC and 270 healthy controls were determined by direct polymerase chain reaction and polyacrylamide gel electrophoresis. Logistic regression was used to analyze the association between the polymorphism and cancer risk.

Results

Computational modeling suggested that rs6147150 was located in the seed region of hsa-let-7c, a potential target sequence in ErbB4 3'UTR. Logistic regression analysis showed that, compared with individuals homozygous for wild-type, heterozygotes [adjusted odds ratio (OR) = 1.48, 95% confidence interv

SUBMITTER: Yu Q 

PROVIDER: S-EPMC3261534 | biostudies-literature | 2012 Jan

REPOSITORIES: biostudies-literature