Structural and functional protein network analyses predict novel signaling functions for rhodopsin.

ABSTRACT: Orchestration of signaling, photoreceptor structural integrity, and maintenance needed for mammalian vision remain enigmatic. By integrating three proteomic data sets, literature mining, computational analyses, and structural information, we have generated a multiscale signal transduction network linked to the visual G protein-coupled receptor (GPCR) rhodopsin, the major protein component of rod outer segments. This network was complemented by domain decomposition of protein-protein interactions and then qualified for mutually exclusive or mutually compatible interactions and ternary complex formation using structural data. The resulting information not only offers a comprehensive view of signal transduction induced by this GPCR but also suggests novel signaling routes to cytoskeleton dyna

SUBMITTER: Kiel C 

PROVIDER: S-EPMC3261702 | biostudies-literature | 2011 Nov

REPOSITORIES: biostudies-literature