Genetic variation in base excision repair pathway genes, pesticide exposure, and prostate cancer risk.

ABSTRACT:

Background

Previous research indicates increased prostate cancer risk for pesticide applicators and pesticide manufacturing workers. Although underlying mechanisms are unknown, evidence suggests a role of oxidative DNA damage.

Objectives

Because base excision repair (BER) is the predominant pathway involved in repairing oxidative damage, we evaluated interactions between 39 pesticides and 394 tag single-nucleotide polymorphisms (SNPs) for 31 BER genes among 776 prostate cancer cases and 1,444 male controls in a nested case-control study of white Agricultural Health Study (AHS) pesticide applicators.

Methods

We used likelihood ratio tests from logistic regression models to determine p-values for interactions between three-level pesticide exposure variables (none/low/hi

SUBMITTER: Barry KH 

PROVIDER: S-EPMC3261977 | biostudies-literature | 2011 Dec

REPOSITORIES: biostudies-literature