Application of computational systems biology to explore environmental toxicity hazards.

ABSTRACT:

Background

Computer-based modeling is part of a new approach to predictive toxicology.

Objectives

We investigated the usefulness of an integrated computational systems biology approach in a case study involving the isomers and metabolites of the pesticide dichlorodiphenyltrichloroethane (DDT) to ascertain their possible links to relevant adverse effects.

Methods

We extracted chemical-protein association networks for each DDT isomer and its metabolites using ChemProt, a disease chemical biology database that includes both binding and gene expression data, and we explored protein-protein interactions using a human interactome network. To identify associated dysfunctions and diseases, we integrated protein-disease annotations into the protein complexes using the Online M

SUBMITTER: Audouze K 

PROVIDER: S-EPMC3261980 | biostudies-literature | 2011 Dec

REPOSITORIES: biostudies-literature